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Provedor de dados:  Nature Precedings
País:  United Kingdom
Título:  Aluminium - Magnesium Silicate enhances antibacterial activity of Ampicillin trihydrate, against Salmonella gallinarum
Autores:  Madike Ezeibe
George Anosa
Okechi Okorie
Nnenna Elendu-Eleke
Obianuju Okoroafor
Augustine Ngene
Ogechukwu Chikelu
Data:  2012-01-20
Ano:  2012
Palavras-chave:  Pharmacology
Resumo:  Solutions of different concentrations, of Ampicillin trihydrate (AT) and of a formulation of AT in Aluminium Magnesium Silicate (AMS), were used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg / Kg (AT), 10 mg / Kg (AT in AMS), 7.5 mg / Kg ( AT), 7.5 mg /Kg (AT in AMS). Mean inhibition area, 28.39 mm produced by AT did not vary significantly (P ) from 26.36 mm produced by AT in AMS. However, 17.5 105 Salmonella gallinarum culture forming units per ml of bile of the untreated chicks and 3.4 105 (80.58 % reduction), 2.5 105 (85.7 % reduction) , 5.4 105 (69.2 % reduction ) and 0.38 105 (97.8 % reduction ) of the respective treated groups, showed AMS significantly (P 0.01) improved AT`s ability to clear the infection, in vivo.
Tipo:  Manuscript
Identificador:  http://precedings.nature.com/documents/6814/version/1

oai:nature.com:10101/npre.2012.6814.1

http://hdl.handle.net/10101/npre.2012.6814.1
Fonte:  Nature Precedings
Direitos:  Creative Commons Attribution 3.0 License
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